Emerging links between endosomal pH and cancer
نویسندگان
چکیده
منابع مشابه
pH in Cancer: Emerging Concepts
Two common characteristics of malignant solid tumors is a high rate of glucose metabolism, usually measured with FDG PET, and heterogeneous perfusion, usually measured with Contrast Enhanced MRI. The combination of these two characteristics leads to microenvironments that are hypoxic and acidic. It can also be shown that these characteristics are present early in carcinogenesis, and they are si...
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Metabolism generates oxygen radicals, which contribute to oncogenic mutations. Activated oncogenes and loss of tumor suppressors in turn alter metabolism and induce aerobic glycolysis. Aerobic glycolysis or the Warburg effect links the high rate of glucose fermentation to cancer. Together with glutamine, glucose via glycolysis provides the carbon skeletons, NADPH, and ATP to build new cancer ce...
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ژورنال
عنوان ژورنال: Cancer and Metastasis Reviews
سال: 2020
ISSN: 0167-7659,1573-7233
DOI: 10.1007/s10555-020-09870-1